BACE1 / ASP2抗体

BACE1 / ASP2抗体产品信息

免疫原 :
Recombinant human BACE1 protein ( Catalog#10064-HCCH )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human BACE1 extracellular domain ( rh BACE1; Catalog#10064-HCCH; NP_036236.1; Met 1- Thr 457 ). BACE1 specific IgG was purified by human BACE1 affinity chromatography.
BACE1 / ASP2抗体Background
Beta-secretase 1, also known as Beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and ASP2, is a single-pass type I membrane protein. As a member of the peptidase A1 protein family, BACE1 is a integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). APP is cleaved to generate a 40 or 42 amino acid-long amyloid-β peptide, which is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease (AD), and accordingly, BACE1 is implicated in the onset and progression of AD. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD. Different isoforms are derived from four transcript variants.
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三、二抗

编号 名 称
hz-0296Gs Goat anti-Mouse IgG whole serum羊抗小鼠IgG抗血清