FOLR1抗体

FOLR1抗体产品信息

免疫原 :
Recombinant Mouse FOLR1 protein (Catalog#50573-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse FOLR1 (rM FOLR1; Catalog#50573-M08H; NP_032060.2; Met 1-Met 231). FOLR1 specific IgG was purified by Mouse FOLR1 affinity chromatography.
FOLR1抗体 Background
Folate receptor alpha, also known as Adult folate-binding protein, Folate receptor 1, Ovarian tumor-associated antigen MOv18, FOLR1 and FOLR, is a cell membrane protein which belongs to thefolate receptor family. FOLR1 is exclusively expressed in tissues of epithelial origin. Expression of FOLR1 is increased in malignant tissues. It is expressed in kidney, lung and cerebellum. FOLR1 is a membrane bound receptor involved in the transport of folate as well as other regulatory cellular processes. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy.
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五、蛋白质与多肽

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