ASAH2抗体

ASAH2抗体产品信息

免疫原 :
Recombinant mouse ASAH2 protein ( Catalog#50006-M07H )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse ASAH2 ( rM ASAH2; Catalog#50006-M07H; Thr 34-Thr 756; NP_061300.1 ). ASAH2 specific IgG was purified by mouse ASAH2 affinity chromatography.
ASAH2抗体背景综述
ASAH2 (N-acylsphingosine amidohydrolase 2), also known as neutral ceramidase, is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein. This enzyme is abundant in the brush border membranes of the intestine, and also expressed in several tissues such as kidney, brain and liver. The primary structure of neutral ceramidase is highly conserved from bacteria to humans, however, there is a clear difference in the molecular architecture. The murine neutral ceramidase possesses ‘amucin box’, a Ser/Thr/Pro-rich domain glycosylated with O-glycans which is necessary to retain the enzyme on the plasma membrane as a type II integral protein. The major physiological function of neutral ceramidase is the metabolism of dietary sphingolipids, and thus plays a role in the generation of messenger molecules such as sphingosine and sphingosine 1-phosphate.
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