CD147 / BSG抗体

CD147 / BSG抗体产品信息

免疫原 :
Recombinant human CD147 protein ( Catalog#10186-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human CD147. ( rhCD147 ; Catalog#10186-H08H ; NP_940991.1 ; Met 1- His 205 ). CD147 specific IgG was purified by human CD147 affinity chromatography.
CD147 / BSG抗体Background
CD147, also known as Basigin, BSG, and EMMPRIN, is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation, and tumor progression. Enriched on the plasma memebrane of many human cancer (breast cancer, lymphoma, oral squamous cell carcinoma, glioma, melanoma, lung, bladder and kidney carcinomas ) cells, CD147 induces the production and release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction.
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