CDK2 / p33抗体

CDK2 / p33抗体产品信息

免疫原 :
Recombinant human CDK2 protein ( Catalog#10624-H08B )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human CDK2 ( rh CDK2 ; Catalog#10624-H08B ; NP_001789.2 ; Met 1- Leu 298 ). Total IgG was purified by Protein A affinity chromatography.
CDK2 / p33抗体背景综述
CDK2 (cyclin-dependent kinase 2), is a member of the cyclin-dependent kinase family（CDK）of Ser/Thr protein kinases. CDK2 is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the G1/S transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The activation of the CDK2 / cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15. Inhibition of CDK2-cyclin complexes can also be attributed to association with p27Kip1 and p21Waf1 / Cip1. The central role of CDK in cell cycle regulation makes it a promising target for studying inhibitory molecules that can modify the degree of cell proliferation. Activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells such as thymocytes, neurons, and endothelial cells. Some researchers demonstrated an unpredicted participation of CDK2 in the accurate pairing and recombination between homologues during mammalian meiosis. Accordingly, CDK2 was thought to be a crucial regulator of S-phase progression and was evaluated as an anticancer drug target.
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