Angiopoietin-2 / ANG 2抗体

Angiopoietin-2 / ANG 2抗体产品信息

免疫原 :
Recombinant Human Angiopoietin-2 / ANG 2 protein (Catalog#10691-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human Angiopoietin-2 / ANG 2(rh Angiopoietin-2 / ANG 2; Catalog#10691-H08H; NP_001138.1; Met 1-Phe 496).Angiopoietin-2 / ANG 2 specific IgG was purified by Human Angiopoietin-2 / ANG 2 affinity chromatography.
Angiopoietin-2 / ANG 2抗体Background
Angiopoietin 2 (Ang2), closely related to Ang1, is a secreted ligand which binds to the endothelial-specific receptor tyrosine kinase Tie2 with similar affinity. Ang2 is a soluble 70kd growth factor consisting of an amino-terminal coiled-coil domain and a carboxy-terminal fibrinogen-like domain. Tie2 and angiopoietins have been shown to play critical roles in vessel remodeling during angiogenesis, vascular homeostatic responses, and the adult vasculature integrity. Ang2 was initially characterized as an antagonist of Ang1 and Tie2, which competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis.
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