Erythropoietin / EPO抗体

Erythropoietin / EPO抗体产品信息

免疫原 :
Recombinant Rat Erythropoietin / EPO protein (Catalog#80055-R08B)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Rat Erythropoietin / EPO (rR Erythropoietin / EPO; Catalog#80055-R08B; P29676-1; Met 1-Arg 192). Erythropoietin / EPO specific IgG was purified by Rat Erythropoietin / EPO affinity chromatography.
Erythropoietin / EPO抗体 Background
Erythropoietin, also known as EPO, is a secreted protein which belongs to theEPO / TPO family. Erythropoietin / EPO is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Erythropoietin / EPO is produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. EPO is produced mainly by peritubular fibroblasts of the renal cortex. It is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver. Erythropoietin / EPO is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. Erythropoietin / EPO is the hormone that regulates red blood cell production. It plays an important role in the brain's response to neuronal injury. Erythropoietin / EPO is also involved in the wound healing process. Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation. Erythropoietin / EPO binds to the erythropoietin receptor (EPOR) on the red cell surface and activates a JAK2 cascade. EPOR is also found in a large number of tissues such as bone marrow cells and peripheral/central nerve cells, many of which activate intracellular biological pathways upon binding with EPO. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus.
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