KIRREL3 / NEPH2抗体

KIRREL3 / NEPH2抗体产品信息

免疫原 :
Recombinant Mouse KIRREL3 / NEPH2 protein (Catalog#50339-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse KIRREL3 / NEPH2 (rM KIRREL3 / NEPH2; Catalog#50339-M08H; Q8BR86-1; Met 1-Ala 535). KIRREL3 / NEPH2 specific IgG was purified by Mouse KIRREL3 / NEPH2 affinity chromatography.
KIRREL3 / NEPH2抗体Background
Kin of IRRE-like protein 3, also known as Kin of irregular chiasm-like protein 3, Nephrin-like protein 2 and KIRREL3, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. KIRREL3 contains fiveIg-like C2-type (immunoglobulin-like) domains. KIRREL3 is expressed in fetal and adult brain. It is also expressed in kidney, specifically in podocytes of kidney glomeruli. KIRREL3 could be involved in the hematopoetic supportive capacity of stroma cells. KIRREL3 might play a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on appropriate target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin. Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) which is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
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