STX2B抗体

STX2B抗体产品信息

免疫原 :
Recombinant Enterohemorrhagic E. coli (EHEC) STX2B protein (Catalog#40019-E08E)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
13
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS with 5% trehalose
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Enterohemorrhagic E. coli (EHEC) STX2B (Catalog#40019-E08E; Q93EY4; Met 1-Asp 89). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
STX2B抗体 Background
E. Coli STX2B is a subunit of Stx2. It is the B subunit. Stx1 and Stx2 are two major groups of shiga toxins. The shiga toxins (Stx1 and Stx2) are produced by Shigella dysenteriae type 1 and enterohemorrhagic Escherichia coli (EHEC), which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli. A large outbreak caused by a rare Shiga toxin-producing Escherichia coli serotype O104:H4 occurred in Germany in May to July 2011. Shiga toxin-producing Escherichia coli are emerging as a significant source of food-borne infectious disease all over the world. It can cause a series of illnesses such as hemorrhagic colitis, hemolytic uremic syndrome or thrombotic thrombocytopenic purpura and death. The Stx1 and E. Coli STX2B subunits form a pentameric structure that binds to globotriaosylceramidereceptors on eukaryotic cells and promotes endocytosis. Stx2 is composed of a diverse and heterogeneous group of subtypes with differential cytotoxicities in mammalian cells. It has been found to be approximately 400 times more toxic (as quantified by LD50 in mice) than Stx.
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