Gremlin 1 / GREM1抗体

Gremlin 1 / GREM1抗体产品信息

免疫原 :
Recombinant Mouse Gremlin 1 / GREM1 protein (Catalog#50016-M08B)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse Gremlin 1 / GREM1 (rM Gremlin 1 / GREM1; Catalog#50016-M08B; O70326; Met1-Asp184). Gremlin 1 / GREM1 specific IgG was purified by Mouse Gremlin 1 / GREM1 affinity chromatography.
Gremlin 1 / GREM1抗体 Background
GREM1 is a member of the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain and is highly expressed in small intestine, fetal brain and colon. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner and down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. GREM1 also is an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development.
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