IL-23A & IL-12B Heterodimer抗体

IL-23A & IL-12B Heterodimer抗体产品信息

免疫原 :
Recombinant Human IL-23A & IL-12B Heterodimer protein (Catalog#CT012-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human IL-23A & IL-12B Heterodimer (rh IL-23A & IL-12B Heterodimer; Catalog#CT012-H08H; Q9NPF7 & NP_002178.2; Met1-Pro189 & Met1-Ser328). Total IgG was purified by Protein A affinity chromatography.
IL-23A & IL-12B Heterodimer抗体Background
Interleukin-23 subunit alpha, also known as IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19 and IL23A, is a secreted protein which belongs to theIL-6 superfamily. IL-23A associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.Interleukin-12 subunit beta, also known as cytotoxic lymphocyte maturation factor 40 kDa subunit, NK cell stimulatory factor chain 2, NKSF2 and IL12B, is secreted protein which belongs to thetype I cytokine receptor family and Type 3 subfamily. IL12B / NKSF2 is a ctokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. IL12B / NKSF2 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
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