ECM1抗体

ECM1抗体产品信息

免疫原 :
Recombinant human ECM1 protein ( Catalog#10362-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
6C3C6
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human ECM1 ( rhECM1; Catalog#10362-H08H; Met 1- Glu 540; NP_004416.1 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ECM1抗体背景综述
Extracellular matrix protein-1 (ECM1) is a secreted glycoprotein important in connective tissue organization. Three splice variants have been identified: ECM1a (540 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although not tumor specific, ECM1 is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. ECM1 also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling. Two disorders are associated with diminished function of ECM1, referred to as lipoid proteinosis which is a autosomal recessive disorder typified by generalized thickening of skin, mucosae and certain viscera, and an autoimmune disease lichen sclerosis. The pathological phenotypes support a role for ECM1 as a "biological glue" in the dermis, and exerts actions in skin adhesion, epidermal differentiation, wound healing, and basement membrane physiology. Recent studies have revealed that ECM1 is implicated in the common inflammatory bowel diseases, ulcerative colitis and Crohn's disease.
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