DSC2 / Desmocollin-2抗体

DSC2 / Desmocollin-2抗体产品信息

免疫原 :
Recombinant Rat DSC2 / Desmocollin-2 protein (Catalog#80266-R08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Rat DSC2 / Desmocollin-2 (rR DSC2 / Desmocollin-2; Catalog#80266-R08H; Q3T1K6; Met1-Pro694). Total IgG was purified by Protein A affinity chromatography.
DSC2 / Desmocollin-2抗体 Background
Desmocollin-2, also known as Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DSC2 and CDHF2, is a single-pass type I membrane protein which contains five cadherin domains. The desmocollins are members of the desmosomal cadherin family of cell-cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in the maintenance of tissue integrity in epithelia and cardiac muscle. In humans, three desmocollins (DSC1, DSC2 and DSC3) have been described. DSC2 / CDHF2 is component of intercellular desmosome junctions. It is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 / CDHF2 may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death.
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