CD221 / IGF1R抗体

CD221 / IGF1R抗体产品信息

免疫原 :
Recombinant human IGF1R protein ( Catalog#10164-H08H )
克隆号 :
4E2D12F6
Ig Type : Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IGF1R / CD221 extracellular domain ( rhIGF1R; Catalog#10164-H08H; Met 1- Asn 932; NP_000866.1 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD221 / IGF1R抗体 Background
The insulin-like growth factor-1 receptor (IGF1R) is a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1 receptor is a receptor tyrosine kinase (RTK) expressed in all cell types and tissues, and plays a critical role in transformation events during embryogenesis, development and pathogenesis processes. IGF1R become tyrosine phosphorylated and enzymatically activated either in response to IGF1 and 2 ligands or because of the activity of the Src tyrosine kinase, and subsequently initiates an intracellular signaling cascade (MAPK) that leads to gene expression changes and correspondent cellular responses. It is commonly overexpressed in most malignant tissues including breast, prostate, pancreas and affect cancer cell proliferation, adhesion, metastasis and survival by mediating the anti-apoptotic pathway. Accordingly, IGF1R is regarded as potential anti-tumor therapeutic target, and momoclonal antibodies are probably the most promising and specific therapeutic agents.
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