ADAM12 / MLTN 抗体

ADAM12 / MLTN 抗体产品信息

免疫原 :
Recombinant human ADAM12 protein ( Catalog#10896-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
3G1B10B9
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human ADAM12 / MLTN extracellular domain ( rh ADAM12 ; Catalog#10896-H08H ; NP_003465.3 ; Met 1 - Ser 513 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
ADAM12 / MLTN 抗体背景综述
Disintegrin and metalloproteinase domain-containing protein 12, also known as ADAM12 and Meltrin alpha, is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM12 is an active metalloprotease, and has been implicated in insulin-like growth factor (IGF) receptor signaling, through cleavage of IGF-binding proteins, and in epidermal growth factor receptor (EGFR) pathways, via ectodomain shedding of membrane-tethered EGFR ligands. ADAM12 contains one disintegrin domain, one EGF-like domain and one peptidase M12B domain. It is involved in skeletal muscle regeneration, specifically at the onset of cell fusion. It is also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. ADAM12 possesses extracellular metalloprotease and cell-binding functions, as well as intracellular signaling capacities. Interest in ADAM12 has increased because its expression is related to tumor progression and it is a potential biomarker for breast cancer.
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