TNFRI / CD120a抗体

TNFRI / CD120a抗体产品信息

免疫原 :
Recombinant human TNFRI protein ( Catalog#10872-H08H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
7A1C8
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human TNFRI extracellular domain ( rh TNFRI ; Catalog#10872-H08H ; NP_001056.1 ; Met 1 - Thr 211 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
TNFRI / CD120a抗体背景综述
Tumor necrosis factor receptor superfamily, member 1A ( TNFRSF1A) , also known as TNFRI, TNF R-p55/p60, and CD120a, is a type I transmembrane protein widely expressed and is present on the cell surface as a trimer of 55 kDa subunits. Human TNFRI is a 455 aa protein that contains a 21 aa signal sequence, a 190 aa ECD with a PLAD domain which mediates constitutive trimer formation followed by four TNF-α trimer-binding cysteine-rich domains (CRDs), a 23 aa transmembrane domain, and a 221 aa cytoplasmic sequence that contains a neutral sphingomyelinase activation domain and a death domain. TNFRI serves as a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor, and the resulting death-inducing signaling complex (DISC) initiates the subsequent cascade of caspases mediating apoptosis. TNFRI can also activate the transcription factor NF-kB, and functions as a regulator of inflammation. Germline mutations of the extracellular domains of TNFRI are found to be associated with the human genetic disorder called periodic fever syndrome.
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