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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human CD46 (NP_722548.1).
- 保存条件:
Store at -20℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB
- 抗体英文名:
CD46 Antibody
- 抗体名:
CD46 Antibody
- 规格:
50uL
CD46 抗体,CD46 Antibody,CD46 抗体,CD46 Antibody
产品名称:CD46 抗体-CD46 Antibody
产品货号:PSI-16-644-50uL
产品规格:50uL
背景资料:The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
保存建议:CD46 抗体-CD46 AntibodyStore at -20℃
应用类型:WB
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文献和实验CD46 分子 CD46 常用单克隆抗体或代号: HULYM5,J48 主要表达细胞: 广泛,Leu,Pt [NL] 分子质量(kDa)和结构: gp56- 66,膜辅助因子蛋白(MCP) 功 能: 调节补体活化,裂解C3b ,C4b膜辅助因子蛋白 CD46 Aka membrane cofactor protein (MCP) Cofactor for Factor
的多克隆抗体与促衷变因子(DAF)、H因子或CR1均不起反应,从而认为它是补体系统的一种新的调节蛋白,在第四届国际白细胞分型讨论会上将其命名为CD46。 MCP为一单链穿膜糖蛋白,分子量45-70kDa,属于RCA基因簇的成员。也通过GPI锚固定于细胞上。MCP的细胞分布甚广,包括粒细胞、血小板、T细胞(Th、Ts、Tc)、B细胞、NK细胞、造血细胞系、成纤维细胞、表皮细胞、内皮细胞及星状胶质细胞等。但不同类型的细胞上表达的数量有所不同。外周血单个核细胞和粒细胞为1万个/细胞,造血
Detection of Cell Membrane-Bound CD46 Using Flow Cytometry
CD46 is an important regulator of the complement system by preventing unwanted deposition of the complement activation products and opsonins C3b/C4b onto self-tissue. Recently, intracellular signals mediated by CD46 activation
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