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- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
COMP / TSP5 抗体
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human COMP ( rhCOMP; Catalog#10173-H08H; NP_000086.2; Met 1- Ala 757 ). COMP specific IgG was purified by human COMP affinity chromatography.
COMP / TSP5 抗体背景综述
Cartilage Oligomeric Matrix Protein (COMP), also referred to as thrombospondin-5, is a secreted noncollagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. The native glycoprotein incorporates five identical subunits, each with the molecular weight of 87 KDa consists of four epidermal growth factor (EGF)-like domains, eight so-called thrombospondin type 3 (T3) repeats (calcium-binding domain) and a carboxyl-terminal globular domain. A coiled-coil domain at the amino terminus mediates the pentamerization resulting in a bouquet-shaped subunit arrangement via disulfide-bonds. COMP is a component of cartilage, synovium, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+ . COMP is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. COMP mutations cause dominantly inherited chondrodysplasias Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) characterized by short stature and early-onset osteoarthrosi, and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
COMP / TSP5 抗体相关产品如下：xy-0369xy Rabbit IgM(亲和纯化) 兔IgM
xy-0295xy-xyE Rabbit IgG/PE荧光素PE标记兔IgG(细胞流式同型对照)
xy-0295xy-xyy5 Rabbit IgG/Cy5荧光素Cy5标记兔IgG(细胞流式同型对照)
xy-0295xy-Axyxy Rabbit IgG/APC荧光素APC标记兔IgG(细胞流式同型对照)
xya-0297R Rabbit Anti-human IgG/Streptavidin链霉亲和素标记兔抗人IgG
xy-0437xy-xyE Streptavidin/PEPE标记链霉亲和素
xy-0437xy-Axy Streptavidin/AP碱性磷酸酶标记链霉亲和素
xy-0437xy-HRxy Streptavidin/HRP辣根过氧化物酶标记链霉亲和素
xy-0437xy-Golxy Streptavidin/Gold金标记链霉亲和素(10nm/15nm)
xye-0312xy Avidin/HRP辣根过氧化物酶标记亲合素
xye-0302R Rabbit Anti-HRP/HRP辣根过氧化物酶标记兔抗HRP
xye-0360R Rabbit Anti-human IgA/HRP辣根过氧化物酶标记兔抗人IgA
xye-0362xy Protein A/HRP辣根过氧化物酶标记的蛋白A
xye-0292xy BSA/HRP 辣根过氧化物酶标记牛血清白蛋白
xy-0855xy-HRxy Insulin/HRP辣根过氧化物酶标记人胰岛素蛋白
xy-0311xy-Axy Biotin/AP碱性磷酸酶标记生物素
xy-0312xy-Axy Avidin/AP碱性磷酸酶标记亲合素
xy-0360G-Axy Goat Anti-human IgA/AP碱性磷酸酶标记羊抗人IgA
xy-0360R-Axy Rabbit Anti-human IgA/AP碱性磷酸酶标记兔抗人IgA
xy-0362xy-Axy Protein A/AP碱性磷酸酶标记的蛋白A
xyb-0360G Goat Anti-human IgA/Biotin生物素化羊抗人IgA
xy-0295xy-Bio Rabbit IgG/Biotin生物素化兔IgG
xyb-0296xy mouse IgG/Biotin生物素化小鼠IgG
xyF-0366R Rb Anti-FITC/FITC荧光素标记兔抗FITC
xy-0437xy-RBITxy Streptavidin/RBITC红色荧光素罗丹明标记链霉亲和素
xy-0295xy-RBITxy Rabbit IgG/RBITC罗丹明标记兔IgG(细胞流式同型对照)
xyR-0296xy Mouse IgG/RBITC罗丹明标记小鼠IgG(细胞流式同型对照)
xyR-0294xy Goat IgG/RBITC罗丹明标记羊IgG(细胞流式同型对照)
xyR-0293xy Rat IgG/RBITC罗丹明标记大鼠IgG(细胞流式同型对照)
xyF-0312xy Avidin/FITC荧光素标记亲合素
xy-0437xy-FITxy Streptavidin/FITC 荧光素标记链霉亲和素
xyR-0366R Rb Anti-FITC/RBITC罗丹明标记兔抗FITC
xyR-0360G Goat Anti-human IgA/RBITC罗丹明标记羊抗人IgA
xyR-0312xy Avidin/RBITC罗丹明标记亲合素
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文献和实验脾细胞与小鼠骨髓瘤细胞（P3-X63/Ag8）融合，融合的细胞既获得了亲代脾细胞分泌特异性抗体的特性，又具有骨髓瘤细胞大量繁殖的能力，成为一种既能分泌特异性抗体又能长命的杂交瘤细胞。该技术为抗体的分子生物学研究提供了全新的手段。极大地促进了免疫学，遗传学，分子生物学的快速发展。 但传统抗体目前也面临诸多问题，如： 每使用一管新抗体都需要进行滴定测试； 多种同型对照，实验设计繁琐； 需要添加Fc阻断试剂； 抗体不佳，阳性细胞群不明显； 抗体作为细胞生物学和生物化学中最重要的试剂之一，科学界每年在这类
人转录因子E2F1 ( E2F1 )ELISA 试剂盒 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 E2F1 单抗包被于酶标板上，标准品和样品中的 E2F1与单抗结合，加入生物素化的抗人 E2F1 ，形成免疫复合物连接在板上，辣根过氧化物酶标记的 Streptavidin 与生物素结合，加入底物工作液显蓝色，最后加终止液硫酸，在 450nm 处测 OD 值，E2F1 浓度与 OD 值成正比
luozhifeng339 请教各位达达，我准备做EMSA，如果做SUPER-SHIFT的话，该选择原装抗体还是分装的抗体呢，盼不吝赐教！ wanglinling 看到一篇EMSA的文章，不知道里面有没有回答你的问题哈，不过英文的值得阅读哈。 GEL SUPER-SHIFT ASSAY/ EMSA Materials/Reagents: See Gel-shift assay Procedure
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