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- 保存条件:
常温,避光
- 克隆性:
单克隆
- 抗体名:
CNDP1 / CN1 抗体
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human Carnosine Dipeptidase 1 ( rhCNDP1; Catalog#10077-H08H; Ser27-His507; NP_116038.4 ). CNDP1 specific IgG was purified by human CNDP1 affinity chromatography.
CNDP1 / CN1 抗体背景综述
CNDP1, also known as glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. This protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine, and is identified as human carnosinase expressed in the brain. The CN1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protects against the adverse effects of high glucose levels on renal cells. In addition, this protein is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.
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