SerpinD1 / HCII抗体

SerpinD1 / HCII抗体产品信息免疫原 : Recombinant mouse SerpinD1 protein ( Catalog#50121-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse SerpinD1 ( rM SerpinD1 ; Catalog#50121-M08H ; NP_032249.3 ; Met 1 - Ser 478 ). SerpinD1 specific IgG was purified by mouse SerpinD1 affinity chromatography.
SerpinD1 / HCII抗体 Background
Mouse SerpinD1, also known as heparin cofactor II (HCII), is a member of Serpin superfamily of the serine proteinase inhibitors. Mouse HCII is a glycoprotein expressed predominantly in liver that inhibits thrombin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans (GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis.
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