Ephrin-A3 / EFNA3抗体

The ephrins (EPH) and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases (RTKs), and have been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class which are anchored to the membrane by a GPI linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. 14 receptors and 8 ligands have been reported in mammals.
Human ephrin-A3, also known as EPH-related receptor tyrosine kinase ligand 3, EFNA3 and LERK-3, is a cell membrane protein which belongs to the ephrin family. Ephrin-A3 / EFNA3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. EphrinA3 is capable of binding EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, and EphB1. The EphrinA3 ligand may interact with the EphA5 receptor to restrict entorhinal axon terminals in the outer molecular layer of the dentate gyrus. Furthermore, Research evidences indicated that ephrin-A3, but not other ligands, binds to heparan sulfate, and the presence of cell surface heparan sulfate is required for the full biological activity of ephrin-A3.
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