GFRA1 / GFR alpha-1抗体

GFRA1 / GFR alpha-1抗体产品信息免疫原 : Recombinant mouse GFRA1 protein ( Catalog#50171-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse GFRA1 / GFR alpha-1 ( rM GFRA1 ; Catalog#50171-M08H ; AAB86600.1 ; Met 1 - Ser 425 ). Total IgG was purified by Protein A affinity chromatography
GFRA1 / GFR alpha-1抗体背景综述
Mouse GDNF family receptor alpha 1 ( GFRα-1) is a glycosyl phosphatidylinositol (GPI)-linked protein that binds Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGFβ superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by GPI linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret which is necessary for kidney and enteric neuron development. GFRα-1 is the primary receptor for GDNF and GFRα-2 exhibits a preference for NTN. GFRα-3 is expressed only during development. GFRα-1 gene is a candidate gene for Hirschsprung disease
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