IL12B / P40 / NKSF2抗体

IL12B / P40 / NKSF2抗体产品信息免疫原 : Recombinant human IL12B protein ( Catalog#10052-H08H )

抗体类型: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 54
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human IL12B / p40 ( rh IL12B; Catalog#10052-H08H; Met 1-Ser 328; NP_002178.2 )
IL12B / P40 / NKSF2抗体背景综述
Interleukin 12 (IL-12), also known as NKSF or CLMF, is a disulfide-linked heterodimeric cytokine composed of a 35kDa subunit P35 and a 40kDa subunit P40, also designated as IL-12A and IL-12B. IL-12 is predominantly produced by macrophages and B lymphocytes and plays an important role in the activities of natural killer cells and T lymphocytes. It is involved in the differentiation and development of Th1 cells, enhancement of natural killer cells’ cytolytic function and mitogenic effects, as well as induction of IFN-gamma during which it can synergize with other IFN-gamma inducers. A large excess of monomeric IL-12B is also secreted by the cells producing IL-12, and exhibits no demonstrable biological activity. Overexpression of IL-12B has been shown to be associated with the pathogenesis of multiple sclerosis.
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