OMD / Osteomodulin抗体

OMD / Osteomodulin抗体产品信息免疫原 : Recombinant mouse OMD protein ( Catalog#50451-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse OMD ( rM OMD ; Catalog#50451-M08H ; NP_036180.1 ; Met 1 - Ile 423 ). Total IgG was purified by Protein A affinity chromatography
OMD / Osteomodulin抗体背景综述
Mouse Osteomodulin, also known as Osteoadherin, Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, OSAD, SLRR2C and OMD, is a secreted protein which belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin / OMD is the only member restricted to mineralized tissues. Osteomodulin / OMD is primarily expressed by osteoblasts and might have a role in regulation of mineralization. Osteomodulin / OMD was primarily present in bone trabeculae and no staining was seen in cartilage. In situ hybridization showed the strongest expression in osteoblasts close to the cartilage/bone interface of the growth plate and lower expression in diaphyseal osteoblasts. Osteomodulin / OMD is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin / OMD may be implicated in biomineralization processes. It has a function in binding of osteoblasts via the alpha (V) beta (3)-integrin. It is likely that Osteomodulin / OMD is an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin / OMD is also an early marker for terminally differentiated matrix producing osteoblasts.
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