H3N2 HA / Hemagglutinin抗体

H3N2 HA / Hemagglutinin抗体产品信息免疫原 : Recombinant H3N2 (A/Brisbane/10/2007) HA protein (Catalog#11056-V08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant H3N2 (A/Brisbane/10/2007) HA / Hemagglutinin (Catalog#11056-V08H; ABW23353.1; Met 1-Ile 531). Total IgG was purified by Protein A affinity chromatography.
H3N2 HA / Hemagglutinin抗体 Background
Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion "fusion peptide". After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle's own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence. Among the multiple influenza A virus subtypes, H3N2 is one of the three subtypes which mainly infects humans. H3N2 viruses can infect birds, humans, and pigs, and the virus has mutated into many strains.
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