beta-Catenin / CTNNB1抗体

beta-Catenin / CTNNB1抗体产品信息免疫原 : Recombinant Human beta-Catenin / CTNNB1 protein (Catalog#11279-H20B)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human beta-Catenin / CTNNB1 (rh beta-Catenin / CTNNB1; Catalog#11279-H20B; P35222-1; Met 1-Leu 781). beta-Catenin / CTNNB1 specific IgG was purified by Human beta-Catenin / CTNNB1 affinity chromatography.
beta-Catenin / CTNNB1抗体 Background
Catenin beta-1, also known as CTNNB1, is a cytoplasm and nucleus protein which belongs to thebeta-catenin family. Catenin beta-1 / CTNNB1 contains 12ARM repeats. Catenin beta-1 / CTNNB1 is expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Catenin beta-1 / CTNNB1 is also expressed in colon. Catenin beta-1 / CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Catenin beta-1 / CTNNB1 is involved in signal transduction through the Wnt pathway. Nuclear beta-catenin is involved in transcriptional regulation by association with transcription factors of the TCF / LEF family. Defects in CTNNB1 are associated with colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB) susceptibility to ovarian cancer (OC).
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