TH / Tyrosine Hydroxylase抗体

TH / Tyrosine Hydroxylase抗体产品信息免疫原 : Recombinant Mouse TH / Tyrosine Hydroxylase protein (Catalog#50997-M07B)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse TH / Tyrosine Hydroxylase (rM TH / Tyrosine Hydroxylase; Catalog#50997-M07B; P24529; Pro 2-Ser 498). TH / Tyrosine Hydroxylase specific IgG was purified by Mouse TH / Tyrosine Hydroxylase affinity chromatography.
TH / Tyrosine Hydroxylase抗体 Background
Tyrosine Hydroxylase (TH, or TyrH) is the rate-limiting enzyme of catecholamine biosynthesis. Tyrosine Hydroxylase uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. The TH enzyme is inhibited in feedback fashion by the catecholamine neurotransmitters. Dopamine binds to Tyrosine Hydroxylase competitively with tetrahydrobiopterin, and interacts with the R domain. Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. Tyrosine Hydroxylase is modified in the presence of NO, resulting in nitration of tyrosine residues and the glutathionylation of cysteine residues. Tyrosine Hydroxylase involved in the pathogenesis of PD at several different levels, in addition to being a promising candidate for developing new treatments of this disease.
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