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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
常温,避光
- 克隆性:
单克隆
- 抗体名:
CSF1R / M-CSFR / CD115抗体
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human CSF1R / M-CSFR / CD115 (rh CSF1R / M-CSFR / CD115; Catalog#10161-H20B2; NP_005202.2; Lys543-Asp922). CSF1R / M-CSFR / CD115 specific IgG was purified by Human CSF1R / M-CSFR / CD115 affinity chromatography.
CSF1R / M-CSFR / CD115抗体 Background
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1, a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the typeIII subfamily of receptor tyrosine kinases (RTKs), M-CSF receptor is expressed mainly on cells of monocyte/macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CSF receptor homodimerization, and leads to transphosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and thus mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations of this gene have been associated with a predisposition to myeloid malignancy.
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文献和实验Clonality - X Chromosome Inactivation Assay
can utilize X chromosome inactivation (methylation) to determine the clonality status of a tumor or premalignant lesion in females. The technique is based on a methylation-sensitive restriction enzyme and analysis of a polymorphic locus on the X chromosome
. Carlisle( 1956)则提议把第一个命名为感觉孔 X器官( sen- sory pore X organ, SPX),第二个为端髓神经节性 X器官( medulla terminalis ganglionic X or- gan, MTGX),而 M. Gabe( 1954)曾将二者合称为 Hanstrm器官(法 organe de Hanstrm)。 MTGX构成 X器官 -血窦腺系统而参与抑制蜕皮和抑制卵巢成熟,至于促进蜕皮作用据谓是由 MTGX和 SPX二者来完成的。两器官
Agronomic Experiences with Miscanthus x giganteus in Illinois, USA
Since 2002, researchers at the University of Illinois, Urbana-Champaign, Illinois, have been studying the perennial warm-season grass Miscanthus � giganteus (M . � g .) to determine its potential as a biomass feedstock. M . � g . originated
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