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- 2025年07月16日
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- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
GIF / Gastric intrinsic factor抗体
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human GIF / Gastric intrinsic factor (rh GIF / Gastric intrinsic factor; Catalog#13544-H08H; P27352-1; Met1-Tyr417). GIF / Gastric intrinsic factor specific IgG was purified by Human GIF / Gastric intrinsic factor affinity chromatography.
GIF / Gastric intrinsic factor抗体 Background
Gastric intrinsic factor, also known as GIF, is a glycoprotein produced by the parietal cells of the stomach. It is a member of the cobalamin transport protein family. Gastric intrinsic factor is required for adequate absorption of vitamin B12 in the terminal ileum. Vitamin B12 is essential for erythrocyte maturation and mutations in the Intrinsic Factor may lead to congenital pernicious anemia. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to gastric intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociates once again and binds to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.
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文献和实验Identification of Mutations in the Human Factor VII Gene
It has been recognized from the early 1800s that activation of coagulation can be initiated by the exposure of subendothelial layers (tissue factor), but it was the 1940s before factor VII (FVII) was included in this event
三句话读懂一篇 CNS：新疗法助力治疗女性不育；能负载活细胞的冷冻微针治疗技术；发现治疗心肌梗死新靶标，...
gastric cancer metastasis via N4-acetylated COL5A1。该项研究系统地阐释了 NAT10 介导的 mRNA 乙酰化修饰促进胃癌细胞转移机制，为通过靶向干预 NAT10 和 ac4C 通路抑制肿瘤演进提供了新的治疗策略。 该研究首次揭示 mRNA 乙酰化修饰参与癌症进展的机制，人类离战胜胃癌又近了一步！图 5：来源 Signal Transduction and Targeted Therapy 6. Cell Metabolism: 揭示 2 型糖尿病血糖
质进行初步分解；盐酸还有杀菌作用。人的壁细胞还分泌内因子（intrinsic factor），这种糖蛋白在胃腔内与食物中的维生素B 12 结合成复合物，使 B 12 在肠管内不被酶分解，并能促进回肠吸收B 12 入血，供红细胞生成所需。如内因子缺乏，维生素B 12 吸收障碍，可导致恶性 贫血 。 颈粘液细胞（nedk mucous cell）：数量很少，位于腺颈部，多呈楔形夹
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