FCGRT & B2M Heterodimer抗体

FCGRT & B2M Heterodimer抗体产品信息免疫原 : Recombinant Human FCGRT & B2M Heterodimer protein (Catalog#CT009-H08H)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Human FCGRT & B2M Heterodimer (rh FCGRT & B2M Heterodimer; Catalog#CT009-H08H; P55899 & P61769; Met1-Ser297 & Met1-Met119). Total IgG was purified by Protein A affinity chromatography.
FCGRT & B2M Heterodimer抗体 Background
IgG receptor FcRn large subunit p51, also known as IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT and FCRN, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. FcRn / FCGRT is a MHC class I like molecule that functions to protect IgG and albumin from catabolism. FcRn / FCGRT binds to the Fc region of monomeric immunoglobulins gamma. It mediates the uptake of IgG from milk. It may play a role in transfer of immunoglobulin G from mother to fetus.Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to thebeta-2-microglobulin family. It contains oneIg-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. It associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules. B2M is necessary for cell surface expression of MHC class I and stability of the peptide binding groove. In fact, in the absence of B2M, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface.FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin (B2M). It forms an MHC class I-like heterodimer. B2M is a component of the class I major histocompatibility complex (MHC). B2M is also an integral component of the FcRn heterodimer. Failure of passive transfer (FPT) is a condition in which neonates do not acquire protective serum levels of maternal antibodies. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog (FcRn) and beta-2-microglobulin (B2M).
FCGRT & B2M Heterodimer抗体相关产品如下：xy-5705R LZTS1假定肿瘤抑制亮氨酸拉链蛋白1抗体
xy-3827R LDHC(Cancer,testis antigen 32)乳酸脱氢酶LDH-C（肿瘤/睾丸抗原32）抗体
xy-6090R LUCA15肿瘤抑制基因LUCA15抗体
xy-9193R LST1淋巴细胞特异性转运蛋白1抗体
xy-4118R LEO1RNA聚合酶相关蛋白LEO1抗体
xy-5408R Phospho-LRP6(Thr1479)磷酸化低密度脂蛋白受体相关蛋白6抗体
xy-5406R phospho-LCK(Tyr394)磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体
xy-4117R LRP5低密度脂蛋白受体相关蛋白5抗体
xy-5407R phospho-LRP5(Thr1492)磷酸化低密度脂蛋白受体相关蛋白5抗体
xy-5409R phospho-LRP1(Ser4523)磷酸化低密度脂蛋白受体相关蛋白1抗体
xy-3948R LKB1苏氨酸蛋白激酶LKB1抗体
xy-9364R LMP7低分子量蛋白7抗体
xy-3861R LIM protein脂肪瘤相关蛋白抗体
xy-10374R Laminin subunit beta-4层粘连蛋白β4抗体
xy-10370R GnRH-associated peptide I黄体激素释放激素/促性腺激素释放激素抗体
xy-15492R LOX蛋白赖氨酸-6-氧化酶抗体
xy-15500R LTK白细胞酪氨酸激酶受体抗体
xy-12386R LMX1A同源盒转录因子LMX1A抗体
xy-12413R LTBP1转化生长因子β1结合蛋白1抗体
xy-12390R Manic Fringe狂躁基因同源蛋白MFNG抗体
xy-12391R Mib1E3泛素蛋白连接酶MIB1抗体
xy-12396R MAML1主导控制样蛋白1抗体
xy-12397R MAML2主导控制样蛋白2抗体
xy-12405R MAPK6丝裂原活化蛋白激酶6抗体
xy-12375R phospho-MST4 + MST3 + STK25 (Thr178 + Thr190 + Thr174)磷酸化丝氨酸/苏氨酸蛋白激酶MST4,MST3,STK25抗体
xy-12372R MEGF10表皮生长因子样蛋白Megf10抗体
xy-15379R MPP4MPP4蛋白抗体
xy-10319R MCM7/CDC47微小染色体维持缺陷蛋白7抗体
xy-9291R MUL1E3泛素连接酶MUL1抗体
xy-3859R MAGP2纤微丝相关糖蛋白2抗体
xy-2353R Mast Cell Chymase肥大细胞类糜蛋白酶1抗体
xym-2059M Metronidazole(1C2)甲硝唑单克隆抗体
xy-3834R MrpL12线粒体核糖体蛋白L12抗体