IL33 / NF-HEV 抗体

IL33 / NF-HEV 抗体产品信息免疫原 : Recombinant human IL-33 protein ( Catalog#10368-HNAE )

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID : 1D11C3F3
抗体宿主 : Mouse IgG2a
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, E.coli-derived, recombinant human IL-33 ( rh IL-33; Catalog#10368-HNAE; NP_254274.1 ; Ser 112 - Thr 270 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
IL33 / NF-HEV 抗体 Background
Interleukin-33 ( IL-33 ), also known as DVS 27 and NF-HEV, is a proinflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells. IL-33 mediates its biological effects via Toll-interleukin 1 receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines. IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
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