JAML / AMICA1抗体

JAML / AMICA1抗体产品信息免疫原 : Recombinant Human JAML / AMICA1 protein (Catalog#10120-H08H)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 08
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAML / AMICA1 (rh JAML / AMICA1; Catalog#10120-H08H; NP_001091996.1; Met1-Leu275). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
JAML / AMICA1抗体 Background
JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), is a member of JAM transmembrane protein family. It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. The Expression of JAML is restricted to the hematopoietic tissues with the exception of liver. It is Expressed in fetal liver, spleen and thymus. JAML mediates adhesive interactions with Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice),a protein which has been shown to localize to the tight junctions of epithelial cells. JAML mediated activation of CAR is required for neutrophil extravasation in addition to other leukocyte/epithelial cell interaction models. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML also enhances myeloid leukemia cell adhesion to endothelial cells.
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