NGF / NGFB抗体

NGF / NGFB抗体产品信息免疫原 : Recombinant Human NGF / NGFB protein (Catalog#11050-HNAC)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 08
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NGF / NGFB (rh NGF / NGFB; Catalog#11050-HNAC; NP_002497.2; Ser122-Arg239). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
NGF / NGFB抗体 Background
As the first one of a series of neurotrophic factors, nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF, was demonstrated to exhibits the growth stimulating activity of NGF. β-NGF is a target-derived secreted homodimeric protein of two 120-amino acid mature polypeptides after proteolytic removal of the signal and pro peptide. NGF acts via at least two receptors on the surface of cells, TrkA and p75 receptors to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In additon to its neurotropic activities, studies indicated that NGF may also have an important role in the regulation of the immune system. The synthesis of β-NGF in astrocytes is enhanced by various other cytokines including IL-1, TNF-α, PDGF and TGF-β.Defects in β-NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) characterized by degeneration of dorsal root and autonomic ganglion cells, as well as sensory and/or autonomic abnormalities.
NGF / NGFB抗体相关产品如下：xy-10353R phospho-c-ABL(Tyr204)磷酸化非受体酪氨酸激酶c-Abl抗体
xy-10352R phospho-c-ABL (Thr754)磷酸化非受体酪氨酸激酶c-Abl抗体
xy-10309R Cenexin1精子尾部结构蛋白抗体
xy-15198R C5orf19 5号染色体开放阅读框19抗体
xy-15313R C9orf1399号染色体开放阅读框139抗体
xy-15314R C9orf1409号染色体开放阅读框140抗体
xy-15315R C9orf1429号染色体开放阅读框142抗体
xy-15317R C9orf1639号染色体开放阅读框163抗体
xy-15318R C9orf1699号染色体开放阅读框169抗体
xy-15321R C9orf173 9号染色体开放阅读框173抗体
xy-15322R C9orf219号染色体开放阅读框21抗体
xy-10225R phospho-CK II beta (Ser209)磷酸化丝氨酸/苏氨酸蛋白激酶II β/casein kinase IIβ抗体
xym-4792M CEA癌胚抗原抗体
xym-4793M CEA癌胚抗原抗体
xy-12323R CDON细胞粘附分子相关蛋白/癌基因下调蛋白抗体
xy-12327R CD59淋巴细胞抗原Ly6c抗体
xy-8929R Cyclin E周期素E抗体
xy-15272R C7ORF507号染色体开放阅读框50抗体
xy-15273R C7orf537号染色体开放阅读框53抗体
xy-15275R C7orf597号染色体开放阅读框59抗体
xy-15279R C7orf647号染色体开放阅读框64抗体
xy-15283R C8orf128号染色体开放阅读框12抗体
xy-15285R C8orf318号染色体开放阅读框31抗体
xy-15286R C8orf338号染色体开放阅读框33抗体
xy-8859R Collagen IIⅡ型胶原蛋白抗体
xy-12356R Alx1软骨蛋白1抗体
xy-12357R CFDP1颅面部发育蛋白1抗体
xy-12338R CPA3肥大细胞羧肽酶A3抗体
xy-15003R C1orf105 1号染色体开放阅读框105抗体
xy-10144R CD35Ⅰ型补体受体抗体（C3b/C4b受体抗体）
xy-10183R CMKLR1趋化样因子受体1抗体
xy-10185R CMKLR1趋化样因子受体1抗体