IL-1RAcP / IL-1R3抗体

IL-1RAcP / IL-1R3抗体产品信息免疫原 : Recombinant Human IL-1RAcP / IL-1R3 protein (Catalog#10121-H08H)

Reagents : PE-conjugated mouse monoclonal antibody
Clone ID : 05
抗体宿主 : Mouse IgG2a
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1RAcP / IL-1R3 (rh IL-1RAcP / IL-1R3; Catalog#10121-H08H; NP_002173.1; Met 1-Glu 359) and conjugated with PE under optimum conditions, the unreacted PE was removed.
IL-1RAcP / IL-1R3抗体 Background
IL-1 receptor accessory protein (IL-1RAcP), also called as IL1R3, is identified as a subunit of membrane-bound form of the IL-1 receptor. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. Two alternative splice variants of IL-1RacP have been identified: membrane-bound IL-1RAcP (mIL-1RAcP) promotes intracellular IL-1 signalling whereas soluble IL-1RAcP (sIL-1RAcP) contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action. As an indispensible molecule in the IL-1receptor signal transduction, IL-1RAcP is necessary to link eventson the plasma membrane level to downstream signaling pathways. The intracellular signaling of IL-1 mediated by the membrabe receptor involves formation of a ternary receptor complex containing IL1RAcP, IL1R1, adapter protein MyD88, and IL-1R-associated kinases IRAK1 or IRAK2 which is capable of associating directly with either IL1R1 or IL1RacP. Subsquently, multiple cellular responses are generated including NF-κB activation, IL-2 secretion, and IL-2 promoter activation.
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