HAGH / GLO2 / Glyoxalase II抗体

HAGH / GLO2 / Glyoxalase II抗体产品信息免疫原 : Recombinant Human HAGH / GLO2 / Glyoxalase II protein (Catalog#12146-H08E)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 01
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HAGH / GLO2 / Glyoxalase II (rh HAGH / GLO2 / Glyoxalase II; Catalog#12146-H08E; Q16775-2; Met1-Asp260). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
HAGH / GLO2 / Glyoxalase II抗体 Background
Hydroxyacylglutathione hydrolase, also known as Glyoxalase II, HAGH and GLO2, is a mitochondrion matrix and cytoplasm protein which belongs to themetallo-beta-lactamase superfamily and Glyoxalase II family. Glyoxalase II (HAGH / GLO2) is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. The glyoxalase II (HAGH / GLO2) activity in normal human muscle was very low, and the activity was unaltered in muscle of patients with Duchenne and other major forms of muscular dystrophies and spinal muscular atrophy. The selective decrease of glyoxalase I activity in recessively inherited muscular dystrophies may have some relevance to some phases of these disease processes.
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