JAG1 / Jagged 1抗体

JAG1 / Jagged 1抗体产品信息免疫原 : Recombinant Human JAG1 / Jagged 1 protein (Catalog#11648-H08H)

Reagents : PE-conjugated mouse monoclonal antibody
Clone ID : 03
抗体宿主 : Mouse IgG2a
Concentration : 5 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAG1 / Jagged 1 (rh JAG1 / Jagged 1; Catalog#11648-H08H; NP_000205.1; Met1-Ser1046) and conjugated with PE under optimum conditions, the unreacted PE was removed.
JAG1 / Jagged 1抗体 Background
Protein jagged-1, also known as JAG1, JAGL1 and CD339, is a single-pass type I membrane protein which contains 1DSL domain and 15EGF-like domains. JAG1 is widely expressed in adult and fetal tissues. The expression of JAG1 is up-regulated in cervical squamous cell carcinoma. JAG1 is also expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. JAG1 is a ligand for multiple Notch receptors. It is involved in the mediation of Notch signaling. JAG1 may be involved in cell-fate decisions during hematopoiesis. JAG1 seems to be involved in early and late stages of mammalian cardiovascular development.
JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. Defects in JAG1 are also a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation.
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