IFNGR1 / CD119抗体

IFNGR1 / CD119抗体产品信息免疫原 : Recombinant Human IFNGR1 / CD119 protein (Catalog#10338-H08H)

Reagents : PE-conjugated mouse monoclonal antibody
Clone ID : 05
抗体宿主 : Mouse IgG1
Concentration : 5 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFNGR1 / CD119 (rh IFNGR1 / CD119; Catalog#10338-H08H; NP_000407.1; Met1-Gly245) and conjugated with PE under optimum conditions, the unreacted PE was removed.
IFNGR1 / CD119抗体 Background
The protein IFN-γR1 (IFNGR1) is the ligand-binding chain (alpha) of the high-affinity interferon gamma receptor complex which is a heterodimer of IFN-γ R1 (IFN-γ Rα) and IFN-γ R2 (IFN-γ Rβ). IFN-γ R1 is necessary and sufficient for IFN-γ binding and receptor internalization, whereas IFN-γ R2 is required for IFN-γ signal transduction, but does not bind IFN-γ by itself. IFN-γ R1 is constitutively expressed in most cell types and soluble IFN-γ R1 has been detected in biological fluids. Human IFN-γ R1 cDNA encodes a 499 aa residue protein consisting of a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Upon binding to IFN-γ receptor via its C-terminus, the type II interferon IFN gamma triggers multiple intracellular signalling processes including prevention of viral replication, inhibition of cell growth, modulation of cell differentiation, and induction of growth arrest at mid-G1 in different mammary carcinoma cell lines. A genetic variation or deficiency in IFN-γR1 is associated with susceptibility to Helicobacter pylori infection or mycobacterial disease.
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