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CEACAM1 / CD66a抗体

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  • ¥600 - 3980
  • Abcam
  • 中国/美国/德国
  • xy10822-MM02-P
  • 2025年07月15日
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    上海信裕生物科技有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件：

      常温，避光

    • 克隆性：

      单克隆

    • 抗体名：

      CEACAM1 / CD66a抗体

    • 规格：

      1×10^6 cells/瓶

    CEACAM1 / CD66a抗体产品信息免疫原 : Recombinant Human CEACAM1 / CD66a protein (Catalog#10822-H08H)

    Reagents : PE-conjugated mouse monoclonal antibody
    Clone ID : 02
    抗体宿主 : Mouse IgG1
    Concentration : 5 μl/Test, 0.1 mg/ml
    缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
    制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM1 / CD66a (rh CEACAM1 / CD66a; Catalog#10822-H08H; NP_001020083.1; Met1-Gly428) and conjugated with PE under optimum conditions, the unreacted PE was removed.

    CEACAM1 / CD66a抗体 Background

    Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1), also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. There are two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, and seven CEACAM has been identified in humans including type I transmembrane proteins (CEACAM-1, 3, 4) and GPI-linked molecules (CEACAM-5-8). The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
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