Oct4抗体产品信息免疫原 : A synthetic peptide corresponding to the C-terminus of the Human Oct4.
Reagents : FITC-conjugated mouse monoclonal antibody
Clone ID : 03
抗体宿主 : Mouse IgG2a
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human Oct4, and it was conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Oct4抗体 Background
Oct-4, also known as Oct-3 and POU5F1, is a transcription factor which belongs to the POU family, which is necessary for embryonic stem cell pluripotency. Oct-3 plays a critical role in the self-renewal of undifferentiated embryonic stem cells. Oct-3 forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Oct-3 expression must be closely regulated: too much or too little will cause differentiation of the cells. Oct-3 functions in embryonic development, especially during early embryogenesis.
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