CD5 Antibody

CD5 Antibody Product InformationImmunogen : Recombinant Mouse CD5 protein (Catalog#50403-M08H)

Reagents : FITC-conjugated rabbit monoclonal antibody
Clone ID : 114

Ig Type : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
Formulation : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD5 (rM CD5; Catalog#50403-M08H; NP_031676.3; Met 1-Pro 371) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
CD5 Antibody Background
T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I membrane protein. CD5 contains 3SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
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