LY9 / CD229 / SLAMF3抗体

LY9 / CD229 / SLAMF3抗体产品信息免疫原 : Recombinant Mouse LY9 / CD229 / SLAMF3 protein (Catalog#50504-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 017
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LY9 / CD229 / SLAMF3 (rM LY9 / CD229 / SLAMF3; Catalog#50504-M08H; NP_032560.2; Met 1-Arg 453).
LY9 / CD229 / SLAMF3抗体 Background
T-lymphocyte surface antigen Ly-9, also known as Cell surface molecule Ly-9, Lymphocyte antigen 9, CD229 and LY9, is a single-pass type I membrane protein. Mouse CD229 / LY9 is a cell surface molecule of the CD150 (signaling lymphocyte activation molecule) family. CD229 / LY9 contains oneIg-like C2-type (immunoglobulin-like) domains and oneIg-like V-type (immunoglobulin-like) domains. This family consists of nine leukocyte receptors of the immunoglobulin superfamily that are involved in leukocyte activation. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. The cytoplasmic tail of CD229 binds to SAP, a protein that is defective in X-linked lymphoproliferative syndrome. CD229 is its own ligand and participates in the immunological synapse. CD229 cell surface expression on lymphocytes surface is strongly and differentially regulated within the CD150 family members. CD229 is a pan-lymphocyte marker and mAbs against CD229 are able to down-modulate T-cell activation. CD229 / LY9 may participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.
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