SELL / CD62L / L-selectin抗体

SELL / CD62L / L-selectin抗体产品信息免疫原 : Recombinant Mouse SELL / CD62L / L-selectin protein (Catalog#50045-M08H)

Reagents : PE-conjugated rabbit monoclonal antibody
Clone ID : 414

抗体宿主 : Rabbit IgG
Concentration : 10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SELL / CD62L / L-selectin (rM SELL / CD62L / L-selectin; Catalog#50045-M08H; NP_035476.1; Met 1-Asn 332) and conjugated with PE under optimum conditions, the unreacted PE was removed.
SELL / CD62L / L-selectin抗体 Background
L-selectin (SELL), also known asCD62L, is acell adhesion molecule found onleukocytes. It belongs to theselectin family of proteins, which recognise sialylated carbohydrate groups and are involved in the regulation of leukocyte traffic. Selectins are composed of an N-terminal C-type lectin domain, a single EGF domain, a variable number of short consensus repeat (SCR) domains, a transmembrane region and a cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules.Ligandspresent onendothelialcells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs.
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