EphA2抗体

EphA2抗体产品信息免疫原 : Recombinant Mouse EphA2 protein (Catalog#50586-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 301

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphA2 (rM EphA2; Catalog#50586-M08H; NP_034269.2; Met1-Asn535).
EphA2抗体 Background
Ephrin type-A receptor 2, also known as Epithelial cell kinase, Tyrosine-protein kinase receptor ECK and EPHA2, is a single-pass type I membrane protein which belongs to theprotein kinase superfamily, tyr protein kinase family and ephrin receptor subfamily. EPHA2 is a receptor for members of the ephrin-A family. EPHA2 binds to ephrin-A1, ephrin-A3, ephrin-A4 and ephrin-A5. It plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2. The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosyl- phosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Eph receptors are classified as receptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs.
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