YKL-39 / CHI3L2抗体

YKL-39 / CHI3L2抗体产品信息免疫原 : Recombinant Human YKL-39 / CHI3L2 protein (Catalog#12162-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 213
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human YKL-39 / CHI3L2 (rh YKL-39 / CHI3L2; Catalog#12162-H08H; NP_003991.2; Met1-Leu390).
YKL-39 / CHI3L2抗体 Background
Chitinase-3-like protein 2, also known as Chondrocyte protein 39, YKL-39 and CHI3L2, is a secreted protein which Belongs to theglycosyl hydrolase 18 family. Human cartilage chitinase 3-like protein 2 (CHI3L2, YKL-39) is secreted by articular chondrocytes, synoviocytes, lung, and heart. Highest expression of CHI3L2 / YKL-39 is in chondrocytes, followed by synoviocytes, lung and heart. It is not detected in spleen, pancreas, and liver. CHI3L2 may also be expressed in developing brain and placenta. Increased levels of CHI3L2 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis as well as in some other pathologies and in malignant tumors, particularly in glioblastomas. CHI3L2 / YKL-39 belongs to glycosyl hydrolase family 18 and the most closely related to human cartilage glycoprotein 39 (HC gp-39 or chitinase 3-like protein 1, CHI3L1 or YKL-40), which promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. CHI3L1 / YKL-40 is involved in phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1 / ERK2). CHI3L1 / YKL-40 initiates a signaling cascade which leads to increased cell proliferation, suggesting that this protein could play some role in the inhibition of apoptosis. CHI3L2 / YKL-39, which as CHI3L1 / YKL-40 has significantly increased expression in glioblastomas, also activates signal-regulated kinases ERK1 / ERK2 in human embryonic kidney and human glioblastoma (U87 MG) cells. CHI3L2 / YKL-39 may bind glycan structure with high affinity, but not heparin. It has no chitotriosidase activity.
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