EphB1抗体

EphB1抗体产品信息免疫原 : Recombinant Human EphB1 protein (Catalog#11963-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 022

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human EphB1 (rh EphB1; Catalog#11963-H08H; P54762-1; Met1-Pro540).
EphB1抗体 Background
Ephrin type-B receptor 1, also known as EPH-like kinase 6, Tyrosine-protein kinase receptor EPH-2, EPHB1 and EPHT2, is a single-pass type I membrane protein which belongs to theprotein kinase superfamily, tyr protein kinase family and ephrin receptor subfamily. EPHB1 / EPHT2 contains twofibronectin type-III domains, oneprotein kinase domain and oneSAM (sterile alpha motif) domain. EPHB1 / EPHT2 is a member of the Eph family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. Over- or underexpression of certain Eph receptors has been found in some cancer samples compared to normal tissue. The Eph family tyrosine kinase receptors and their ligands have been implicated in axon guidance and neuronal migration during development of the nervous system. EPHB1 / EPHT2 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule implicated in the regulation of cell migration. EPHB1 / EPHT2 is a receptor for members of the ephrin-B family. It binds to ephrin-B1, ephrin-B2 and ephrin-B3. EPHB1 / EPHT2 may be involved in cell-cell interactions in the nervous system. EPHB1 / EPHT2 plays an important roles in diverse biological processes including nervous system development, angiogenesis, and neural synapsis formation and maturation.
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