Vitronectin / VTN抗体

Vitronectin / VTN抗体产品信息免疫原 : Recombinant Human Vitronectin / VTN protein (Catalog#10424-H07H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 102

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human Vitronectin / VTN (rh Vitronectin / VTN; Catalog#10424-H07H; NP_000629.3; Asp20-Leu478).
Vitronectin / VTN抗体 Background
Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin consists of three domains: the N-terminal Somatomedin B domain, a central domain with hemopexin homology, and a C-terminal domain also with hemopexin homology. The Somatomedin B domain is a close knit disulfide knot and binds to plasminogen activator inhibitor-1 (PAI-1) and stabilizes it. An RGD sequence which is a binding site for membrane bound integrins is also found in Vitronectin. As a component of platelets, Vitronectin serves to regulate proteolysis initiated by plasminogen activation, interacts with the urokinase receptor, and binds to several serpin serine protease inhibitors as well. Accordingly, Vitronectin is suggested to be involved in hemostasis, cell migration, as well as tumor malignancy.
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