小鼠抗鸡MHC ClassI抗体 | Mouse Anti-

【经典文献】balb/c小鼠MHC I和II类表位的分析(程序及网站介绍)

1,5,* 文献介绍及评论： PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd

MHC 四聚体应用：TCR 样抗体研发

培养后，洗脱得到需要的噬菌体。相比杂交瘤技术，噬菌体展示呈现出更强的正向选择性。许多研究团队构建噬菌体肽库来筛选合适的抗体。噬菌体展示技术首先能够分离具备短肽特异性，MHC 限制性等特点的小鼠 MHC I 类抗体。此后，也制备出人类 HLA 相关疾病抗体。3、TCR 样抗体筛选TCR 样抗体的特异性和亲和力高低，决定该抗体好坏。具有 MHC 限制性的特异 T 细胞抗体较难制备。但是，最近几年经过许多团队的努力，利用肿瘤或病毒 T 细胞表位制备 TCR 样本抗体工作得到长足发展。结合噬菌体展示体外

Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenoge

to result predominately from a human anti-mouse major histocompatibility complex (MHC) class II reactivity. Our recent development of NOD-scid IL2rγ null β2m null and NOD-scid IL2rγ null Ab null stocks of mice now make it possible to investigate