Recombinant Human Intercellular Adhesion Molecule-1
库存:
100
供应商:
艾美捷科技
CAS号:
查看说明书
规格:
10ug///1mg///2ug
【ICAM-1】重组人细胞内介入分子1,Recombinant Human Intercellular Adhesion Molecule-1,ICAM-1
产品名称:【ICAM-1】重组人细胞内介入分子1-Recombinant Human Intercellular Adhesion Molecule-1
产品货号:PRO-383
产品规格:10ug///1mg///2ug
来源宿主:大肠杆菌中重组表达
保存建议:【ICAM-1】重组人细胞内介入分子1-Recombinant Human Intercellular Adhesion Molecule-1Store at 4℃ if entire vial will be used within 1-2 weeks.Store, frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.
背景资料:ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction, cell signaling and lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18, or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes and endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF?) and is expressed by the vascular endothelium, macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.ICAM-1 is implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be notably elevated in patients with SAH.Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions.
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