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- 详细信息
- 文献和实验
- 技术资料
- 克隆性:
多克隆
- 抗体英文名:
HDAC6 Antibody,HD6,HDAC-6,histone deacetylase 6,JM21
- 规格:
100 ug
产品名称:HDAC6抗体|HDAC6 Antibody,HD6,HDAC-6,histone deacetylase 6,JM21
【产品形式】:艾美捷为您提供的HDAC6抗体产品为100 ug 无色溶液,其浓度为0.2 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该HDAC6抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:Human HDAC6 (1215 a.a. residues) possesses two separate putative catalytic domains, both of which are fully functional and contribute independently to the overall activity of HDAC6. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. HDAC6 may participate in coordinating expression of a group of genes involved in the remoldeling of chromatin during cell differentiation.
BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有 卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代 谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理, 艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
点击:HDAC6抗体,查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:HDAC,HDAC6抗体
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文献和实验Histone Deacetylase Activity Assay
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from the ɛ-amino groups of conserved lysine residues in the amino terminal tail of histones. In humans, there are 18 potential deacetylase enzymes
HDAC(Histone Deacetylase)组蛋白去乙酰化酶活性测定及药物筛选方案
DAC(Histone Deacetylase)组蛋白去乙酰化酶活性测定及药物筛选方组蛋白去乙酰化酶 (histone deacetylase,HDAC )是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离,核小体结构松弛,从而使各种转录因子和协同转录因子能与DNA结合位点特异性结合,激活基因的转录。在细胞核内,组蛋白乙酰化与组蛋白去乙酰化过程处于动态平衡,并由组蛋白乙酰化转移 酶(histone
Evaluation of Histone Deacetylase Inhibitors as Therapeutics for Neurodegenerative Diseases
Various neurodegenerative diseases are associated with aberrant gene expression. We recently identified a novel class of pimelic o -aminobenzamide histone deacetylase (HDAC) inhibitors that show promise as therapeutics
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