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- 详细信息
- 文献和实验
- 技术资料
- 克隆性:
多克隆
- 抗体英文名:
TLR4 Antibody,TOLL,Toll Like Receptor 4
- 规格:
100 ug
产品名称:TLR4抗体|TLR4 Antibody,TOLL,Toll Like Receptor 4
【产品形式】:艾美捷为您提供的TLR4抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该TLR4抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:TLR4 (Toll-like receptor 4) is a mammalain homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of IL-1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-kB.
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点击:TLR4抗体,查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:TLR,TLR4抗体
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文献和实验Analysis of the Functional Role of Toll-Like Receptor-4 Tyrosine Phosphorylation
phosphorylation of TLR4, the principal sensor of Gram-negative bacterial lipopolysaccharide (LPS) plays a role in TLR4 signal-transducing functions. We found that LPS induced TLR4 tyrosine phosphorylation and mutations of tyrosine residues in the Toll-IL
Practical Techniques for Detection of Toll-Like Receptor-4 in the Human Intestine
to be able to respond to pathogenic organisms while at the same time maintain tolerance to normal commensal flora. Toll-like receptors (TLRs) play an important role in this delicate balance. TLRs are transmembrane noncatalytic receptor proteins that induce
【信息】The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Review Nature Reviews Immunology 7, 353-364 (May 2007) | doi:10.1038/nri2079 The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling Luke A. J. O'Neill1 & Andrew G. Bowie1 About the authors Summary TLR (Toll
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